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KMID : 0377519810060040591
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Chung-Ang Journal of Medicine
1981 Volume.6 No. 4 p.591 ~ p.608
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Normal Mercury Concentrations in Blood, Urine and Hair of the Korean Male Adults
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Chung Kyou-Chull
Joo Duck-Won
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Abstract
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For a purpose of searching a rational means of estimating an amount of mercury absorption in normal metabolic process, and to obtain data concerning normal concentrations of mercury in blood, urine and hair of the male adults living in Seoul, Korea, 58 male volunteers aged from 20 to 30 years of age who had no obvious exposure to mercury for occupational and/or therapeutic purposes were selected, and mercury concentrations in blood, urine and hair specimens collected from them were analyzed by dithizone calorimetric method. 1. Frequency distribution of mercury concentrations in urine and hair specimens were well fitted to the log-normal distribution with the equivalent sample means and standard deviations, and that of mercury in blood was fitted to both the normal and the log-normal distributions. 2. Mean mercury concentration in the 24-hour urine specimens was ln^-1 2.48 ㎍/ℓ±ln^-1 0.67㎍/ℓ (x￣_g±s_g=11.95㎍/ℓ;X_max-X_min=23.3㎍/ℓ∼6.12㎍/ℓ). 3. Frequency distribution of mercury concentrations in the 24-hour urine specimens was better fitted to the log-normal distribution when the value was adjusted by specific gravity of urine 1.024 or per gram of creatinine excretion per liter of urine. Mean value of mercury excretion in the 24-hour urine specimens was ln^-1 2.88㎍/ℓ×((0.024/S.G.-1.000)±ln^-1 0.60㎍/ℓ) × ((0.024/S.G.-1.000)(x￣_g±s_g=1. 81㎍/ℓ))×((0.024/S.G.-1.000)±1.65㎍/ℓ)×(0.024/S.G.-1.000);X_max∼X_min=(29.9㎍/ℓ×(0.024/S.G.-1.000)-11.0㎍/ℓ×(0.024/S.G.-1.000)), and ln^-1 2.89㎍/g · creatinine/ℓ±ln^-1 0.62㎍/g·creatinine/ℓ (x￣_g±s_g=18.0㎍/g)·creatinine/ℓ±1.86㎍/g · creatinine/ℓ;X_max∼X_min=33.5㎍/g·creatinine/ℓ∼9.7㎍/g·creatinine/ℓ),respectively. 4. Frequency distribution of mercury concentrations in hourly-voided urine specimens was fitted to the log-normal distribution as well, showing the mean of ln^-1 3.07㎍/g·creatinine/ℓ±ln^-1 0.77㎍/g·creatinine/ℓ(x￣_g±s_g=21.5㎍/g·creatinine/ℓ±2.16㎍/g·creatinine/ℓ);X_max∼X_min=46.4㎍/g·creatinine/ℓ∼10.0㎍/g·creatinine/ℓ) with greater dispersion of mercury excretion than in the 24-hour urine specimens. 5. Mercury excretion in the hourly-voided urine specimens showed a diurnal varition (p<0.01), as minimal as ln^-1 2.72㎍/g·creatinine/ℓ±ln^-1 0.76㎍/g·creatinine/ℓ(x￣_g±s_g=15.2㎍/g·creatinine/ℓ±2.14㎍/g·creatinine/ℓ);X_max∼X_min=32.5㎍/g·creatinine/ℓ±7.10㎍/g·creatinine/ℓ) in urinevoided at 6 o’clock in the morning and as maximal as ln^-1 3.34㎍/g·creatinine/ℓ+ln^-1 0.58㎍/g·creatinine/ℓ (x￣_g±s_g=26.6㎍/g·creatinine/ℓ±2.10㎍/g·creatinine/ℓ);X_max∼X_min=55.9㎍/g·creatinine/ℓ∼12.7㎍/g·creatinine/ℓ) in urine viided at 1 o’clock in the afternoon. 6. Frequency distribution of mercury concentrations in blood was fitted to both the normal and the log-normal distributions with the arithmetic mean of x￣±s=30.2㎍/100ml±14.96㎍/100ml and the geometric mean of ln^-1 3.23㎍/100ml±ln^-1 0.57㎍/100ml(x￣_g±s_g=25.3㎍/100ml±1.77㎍/100ml;X_max∼X_min=44.8㎍/100ml∼14.29㎍/100ml). 7. Frequency distribution of mercury concentrations in hair was log-normally distributed with the mean of ln^-1 0.45㎍/㎍/g±ln^-1 0.56㎍/g(x￣_g±s_g=1.57㎍/g;X_max∼X_min=2.75㎍/g∼0.90㎍/g) 8. Frequency distribution of mercury concentrations in urine, when expressed in terms of ㎍ per liter, was well fitted to the logarithmic, exponential and power curves with that in hair (㎍/g). No relationship, however, was found between mercury in urine and in blood (㎍/100ml), and between mercury in blood and in hair.
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